A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure | Synapse
April 22, 2026Open Access
A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure
Key Points
The research aims to investigate the effects of a psychedelic drug on synaptic physiology linked to prenatal alcohol exposure.
Administered a single dose of a psychedelic drug to a mouse model of prenatal alcohol exposure.
Measured changes in synaptic physiology within the prefrontal cortex.
Observed improvements in synaptic function in the prefrontal cortex after treatment.
Identified potential neuroplastic effects of the psychedelic drug on synaptic deficits.
Abstract
Psychedelic neuroplastogens may show promise as potential therapeutics for synaptic deficits associated with PAE and should be further explored in preclinical models.