Insomnia was significantly associated with an increased risk of incident atrial fibrillation (adjusted HR 1.14; 95% CI 1.10-1.18).
Cohort (n=1,780,764)
Yes
Does insomnia increase the risk of incident atrial fibrillation in individuals without prior cardiovascular disease?
Insomnia is an independent risk factor for incident atrial fibrillation in a large, real-world Japanese cohort without prior cardiovascular disease.
Effect estimate: HR 1.14 (95% CI 1.10-1.18)
Background: Insomnia is one of the most prevalent diseases observed in clinical practice, contributing to increased death and a range of chronic diseases. While numerous studies have explored the relationship between insomnia and cardiovascular disease, research on its association with atrial fibrillation (AF) remains limited. This study aimed to investigate the association between insomnia and incident AF in the general population by comprehensive, nationwide, real‐world data in Japan. Methods: A total of 1 780 764 individuals without prior cardiovascular disease including AF from the DeSC database were included between April 2014 and August 2023. Insomnia was defined by International Classification of Diseases , Tenth Revision ( ICD‐10 ) codes (F510, G470) before the baseline health checkup. The primary outcome was incident AF (I480–I482 and I489). Cox proportional hazards models were used to estimate hazard ratios of AF according to present insomnia (versus absent). Results: Insomnia was observed in 216 919 individuals (12.2%), showing a significant association with incident AF after adjusting for potential confounding factors (adjusted hazard ratio, 1.14 95% CI, 1.10–1.18). Among subgroups, a similar pattern in the association between insomnia and incident AF was seen, while the association was stronger in younger individuals aged <65 years (versus ≥65 years) and women (versus men) ( P for interaction=0.01 and 0.03, respectively). Conclusions: Insomnia was significantly associated with the risk of AF. It highlighted the importance of recognizing insomnia as a risk factor for AF, given its high prevalence in the general population and the substantial impact of AF on quality of life and prognosis.
Masuda et al. (Mon,) conducted a cohort in Atrial Fibrillation (n=1,780,764). Insomnia vs. Absent insomnia was evaluated on Incident atrial fibrillation (HR 1.14, 95% CI 1.10-1.18). Insomnia was significantly associated with an increased risk of incident atrial fibrillation (adjusted HR 1.14; 95% CI 1.10-1.18).