Inhibition of Transglutaminase 2 Preserves Blood–Brain Barrier Integrity and Improves Neurological Outcomes After Experimental Traumatic Brain Injury in Mice
The aim is to evaluate how inhibiting transglutaminase 2 affects blood-brain barrier integrity and neurological outcomes following traumatic brain injury.
Conducted experiments on mice with induced traumatic brain injury
Inhibited TGM2 to assess effects on blood-brain barrier and neurological performance
Analyzed changes in IL-17 and MMP-9 levels
Inhibition of TGM2 preserved the integrity of the blood-brain barrier
Significantly improved neurological outcomes were observed in treated mice
Alterations in the IL-17-MMP-9 axis contributed to the outcomes
Abstract
TGM2 is a key molecule affecting the BBB after TBI. Inhibition of TGM2 can alleviate the blood-brain barrier and neurological deficits after TBI, acting through the IL-17-MMP-9 axis.