This paper presents a clinical and experiential account of differential responses to transdermal oestrogen gel and patch in the context of co-occurring premenstrual dysphoric disorder (PMDD) and complex post-traumatic stress disorder (CPTSD). It integrates transdermal pharmacology, neuroendocrine sensitivity, and trauma-related neurophysiology through the Trauma-Driven Mode (TDM) framework developed in The Healing Threads. The analysis proposes that hormonal responses are state-dependent and shaped by interactions between endocrine input and autonomic nervous system regulation, offering a biopsychosomatic perspective on variability in hormone replacement therapy outcomes.
The Healing Threads (Mon,) studied this question.