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18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity | Synapse

April 22, 2026

18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity

Key Points

The aim is to compare the imaging performance of 18F-FDG and 68Ga-FAPI-04 in detecting papillary renal neoplasm with reverse polarity.
Utilized 68Ga-FAPI-04 and 18F-FDG PET/CT imaging techniques.
Analyzed imaging results from a 75-year-old woman with PRNRP.
Confirmed diagnosis via postsurgical pathology.
18F-FDG showed intense uptake (SUVmax: 20.8) in the renal pelvis lesion.
68Ga-FAPI-04 exhibited no detectable uptake in the same lesion.
Pathological findings confirmed the diagnosis of PRNRP.

Abstract

Papillary renal neoplasm with reverse polarity (PRNRP) is very rare. Herein, we report a case of imaging findings of PRNRP in a 75-year-old woman. On the 68 Ga-FAPI-04 PET/CT and 18 F-FDG PET/CT image, it presented as a soft-tissue nodule in the left renal pelvis with intense FDG uptake (SUVmax: 20.8) but no FAPI uptake. Postsurgical pathology supported a diagnosis of PRNRP.

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Cite This Study

Yao et al. (Mon,) studied this question.

synapsesocial.com/papers/69e866c96e0dea528ddeb263 https://doi.org/https://doi.org/10.1097/rlu.0000000000006494

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