Background The renal Doppler ultrasound shows an effective and reliable method for evaluation of fluid administration and response to fluid in sepsis patients. Aim This research aimed to investigate renal resistive index (RRI) predictive value in sepsis patients in detecting the response to fluid administration, considering the changes in RRI values over 7 days from admission. Patients and methods This prospective observational cohort study was performed on 45 participants who presented to ICU with suspected or evident diagnosis of sepsis based on sepsis 3 criteria. The participants were categorized into two groups: a fluid nonresponsive group ( n =14) and a fluid responsive group ( n =31). Results There were changes in hemodynamics, acid base disturbance and lactate, these changes were going with the changes in RRI values which were high in most of participants on admission and gradually improved in fluid responsive group with fluid resuscitation but elevated or maintained in fluid nonresponsive group. RRI can significantly predict fluid responsiveness with high sensitivity and specificity. Fluid nonresponsive participants possessed a significantly longer ICU stay in comparison with fluid responsive participants ( P <0.001). The mortality rate within 28 days was substantially greater among fluid nonresponsive participants in comparison with fluid responsive participants ( P =0.022). Conclusion Based on Doppler ultrasound, RRI is a rapid, noninvasive, and bedside technique with good predictive value for evaluation fluid administration and predicting fluid responsiveness in sepsis patients. RRI is a valuable tool in predicting fluid responsiveness with high sensitivity and high specificity.
Aboelfetoh et al. (Wed,) studied this question.