Tandem and mild synthesis of a symmetric secondary alcohol toward an ionizable lipid analogue of DLin-MC3-DMA

Key Points

• The aim is to develop a method for synthesizing a symmetric secondary alcohol that can facilitate mRNA delivery.
• Conducted a tandem reaction involving methyl linoleate to produce symmetric secondary alcohol.
• Developed a method to access ionizable lipids that enhance the delivery of mRNA.
• Successfully synthesized a symmetric secondary alcohol.
• Created CLin-17, an ionizable lipid analogue, showing potential in mRNA delivery comparable to DLin-MC3-DMA.