What does this research mean for the field?

Coronary arterial age demonstrates comparable prognostic performance to chronological age for short-term mortality and meaningfully refines risk stratification among high-risk patients with COVID-19. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to assess the prognostic value of coronary arterial age compared to chronological age for predicting mortality in COVID-19 patients.

April 22, 2026

Coronary arterial age for mortality prediction and risk reclassification in SCORE COVID-19 registry: When vascular age runs faster or slower than chronological age

Key Result

Coronary arterial age demonstrated comparable prognostic performance to chronological age for short-term mortality and refined risk stratification among high-risk patients with COVID-19.

Key Points

The aim is to assess the prognostic value of coronary arterial age compared to chronological age for predicting mortality in COVID-19 patients.
Evaluated coronary arterial age using chest CT imaging
Analyzed short-term mortality outcomes in patients from the SCORE COVID-19 registry
Conducted risk reclassification analysis based on vascular age findings
Coronary arterial age had similar predictive capability for short-term mortality as chronological age
BioAge enhanced risk stratification for patients at high clinical risk
Vascular ageing provided additional clinically relevant insights in COVID-19 cases

Structured PICO

Does coronary arterial age (CAA) improve mortality prediction and risk reclassification compared to chronological age in COVID-19 patients?

Population

Patients in the SCORE COVID-19 registry

Intervention

Coronary arterial age (CAA) / BioAge assessment via chest CT imaging

Comparator

Chronological age

Outcome

Short-term mortalityhard clinical

Coronary arterial age derived from chest CT refines risk stratification for short-term mortality in high-risk COVID-19 patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

CAA demonstrated prognostic performance comparable to chronological age for short-term mortality in COVID-19 and added clinically relevant information on vascular ageing. BioAge meaningfully refined risk stratification among patients at high clinical risk, supporting its use as an adjunctive biomarker whenever chest CT imaging is available.

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Cite This Study

Cereda et al. (Tue,) reported a other. Coronary arterial age demonstrated comparable prognostic performance to chronological age for short-term mortality and refined risk stratification among high-risk patients with COVID-19.

synapsesocial.com/papers/69e867136e0dea528ddeb675 https://doi.org/https://doi.org/10.1093/ageing/afag096

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