A Novel Manganese Glycerophosphate Vaccine Gel Elicits Broad and Durable Immunity Across an Aged and Pox Virus Model

Key Points

• This research aims to evaluate the efficacy of a manganese glycerophosphate vaccine gel in eliciting immunity against pox virus, especially in aged models.
• Developed a subunit vaccine composed of a protein antigen and adjuvant
• Tested vaccine gel in aged and pox virus models
• Assessed immune response durability and breadth
• The vaccine gel generated a broad immune response in aged models
• Immunity was durable over an extended period
• Elicited a strong response against pox virus