Development and External Validation of a Parsimonious Endocrine–Metabolic Model for 12-Month Pregnancy Prediction in Women With PCOS

Key Points

• The aim is to develop and externally validate a model for predicting 12-month pregnancy outcomes in women with PCOS.
• Developed an endocrine-metabolic model for pregnancy prediction
• Validated the model's accuracy across various populations
• Created a web calculator for clinical use
• The model shows validated discrimination for predicting pregnancy outcomes
• The decision-analytic utility is demonstrated for clinical implementation
• Local recalibration improves accuracy across different populations