Methotrexate toxicity in the setting of oral therapeutic errors: a multicenter retrospective study

Key Points

• This study aims to evaluate the toxicity linked to daily administration of methotrexate due to therapeutic errors.
• Conducted as a multicenter retrospective analysis
• Examined cases of patients who experienced organ dysfunction after daily methotrexate administration
• Identified and classified types of therapeutic errors
• Relatively low doses of methotrexate led to severe organ dysfunction
• Therapeutic errors occurred more frequently than anticipated
• Findings suggest a need for stricter monitoring during methotrexate treatment