This research aims to understand how gut microbiota influences schizophrenia via cerebrospinal fluid metabolites.
Examined associations between gut microbiota and cerebrospinal fluid metabolites.
Analyzed data to determine causal relationships within the gut-brain axis.
Found specific gut microbiota profiles linked to schizophrenia.
Identified distinct cerebrospinal fluid metabolites associated with these profiles.
Abstract
These findings support causal links between specific gut microbiota, CSF metabolites, and schizophrenia, highlighting potential mechanisms within the gut-brain axis.