Ginsenoside Rg3-containing ionizable lipid nanoparticles for siRNA delivery

Key Points

• To investigate the use of ginsenoside Rg3 in lipid nanoparticles for effective siRNA delivery while addressing safety concerns associated with cholesterol.
• Utilized ginsenoside Rg3 to formulate ionizable lipid nanoparticles.
• Evaluated the efficacy of these nanoparticles in delivering siRNA.
• Assessed the safety profile compared to traditional cholesterol-containing LNPs.
• Ginsenoside Rg3-enhanced siRNA delivery effectiveness was observed.
• Reduced adverse effects were indicated when compared to formulations with cholesterol.
• Demonstrated potential for safer nucleic acid delivery methods.