Evaluation of Regenerative Endodontic Therapy in Young Permanent Teeth with Pulp Necrosis: A Retrospective Study

Objective: This retrospective study aimed to evaluate the clinical and radiographic outcomes of regenerative endodontic therapy using mineral trioxide aggregate in immature permanent teeth with pulp necrosis over a 24-month follow-up period.Methods: The study included 26 pediatric patients aged 8–13 years who were treated at the Department of Pediatric Dentistry, Marmara University Faculty of Dentistry, . Clinical and radiographic records from these patients were analyzed. A standard two-visit regenerative endodontic therapy protocol was employed with MTA. The Periapical Index (PAI) and Cvek root development classification were utilized to evaluate the treatment outcomes. Clinical success was determined by the absence of symptoms such as spontaneous or provoked pain, sensitivity to percussion and palpation, the presence of fistula, abscess, or pathological mobility. Radiographic success was assessed based on PAI scores, root resorption, and lamina dura/PDL findings.Results: The study found an overall clinical success rate of 54% after 24 months. Clinical failures were associated primarily with multi-rooted teeth, which exhibited a higher failure rate compared to single-rooted teeth. Radiographically, there was a significant improvement in root development (Cvek score) over time, with 54% of teeth showing complete root development with full apical closure by the end of the study period.Conclusion: RET using MTA demonstrates moderate clinical success in treating immature permanent teeth with pulp necrosis. The findings highlight the importance of rigorous treatment protocols and careful monitoring to optimize RET outcomes, especially in managing microbial contamination and achieving adequate isolation in pediatric patientsKeywords: Young permanent teeth, pulp necrosis, regenerative endodontic therapy, mineral trioxide aggregate