A ZIF-8-modified electrochemical biosensor for sensitive Aβ aggregation monitoring and Alzheimer's disease drug screening

Key Points

• The research aims to develop an electrochemical biosensor based on ZIF-8 to monitor beta-amyloid-42 aggregation.
• Designed a ZIF-8-modified biosensor.
• Measured current changes in response to Aβ aggregation.
• Tested the sensor for potential drug screening applications.
• Detected changes in current based on beta-amyloid-42 aggregation states.
• Showed that the biosensor effectively interacts with ZIF-8.
• Indicated potential for drug screening in Alzheimer's disease.