Physical exercise mitigated chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis in both an atherosclerotic mouse model and patients with CAD.
Does physical exercise mitigate chronic psychological stress-induced vascular inflammation in atherosclerotic mice and patients with CAD?
Physical exercise mitigates chronic psychological stress-induced vascular inflammation via the monocyte BDNF-Kif4-TARM1 axis.
Chronic psychological stress drives systemic inflammation through neuroimmune mechanisms, thereby accelerating the progression of coronary artery disease (CAD). Physical exercise alleviates stress-induced neuroimmune crosstalk, partly by suppressing proinflammatory responses in monocytes/macrophages. This study provides novel insights into exercise-regulated neuroimmune mechanisms involving the monocyte BDNF-Kif4-TARM1 axis. In both an atherosclerotic mouse model and patients with CAD, exercise mitigated stress-induced inflammation via the BDNF-Kif4-TARM1 axis.
Zheng et al. (Wed,) conducted a other in Coronary artery disease (CAD). Physical exercise was evaluated on Stress-induced inflammation. Physical exercise mitigated chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis in both an atherosclerotic mouse model and patients with CAD.