Nordihydroguaiaretic acid attenuates TNFα-dependent intercellular adhesion molecule-1 expression in cultured human umbilical vein endothelial cells via targeting TNFα-PI3K-NF-κB-ICAM1 pathway.

Key Points

• The research aims to explore how NDGA impacts ICAM1 expression through the TNFα-PI3K-NF-κB pathway.
• Cultured human umbilical vein endothelial cells were treated with NDGA and TNFα.
• ICAM1 expression levels were measured post-treatment.
• NDGA significantly decreased ICAM1 expression.
• The treatment impaired the translocation of NF-κB from the cytoplasm to the nucleus.