What question did this study set out to answer?

The aim is to evaluate predictors of ypN0 status in cN1 breast cancer patients after neoadjuvant therapy.

April 23, 2026Cancer Medicine0 citationsOpen Access

Research on Omitting Sentinel Lymph Node Biopsy after Neoadjuvant Therapy in cN1 Breast Cancer Patients

JSJiabei Shang JCJianzhe Chen RZRuchun Zheng

Key Points

The aim is to evaluate predictors of ypN0 status in cN1 breast cancer patients after neoadjuvant therapy.
Analyzed response markers like bpCR and MRI-rCR(LN) in patients receiving neoadjuvant therapy.
Identified the association between response markers and ypN0 status in cN1 breast cancer.
Patients achieving bpCR and MRI-rCR(LN) frequently converted to ypN0 status.
Luminal B HER2+ patients exhibited higher response rates compared to other subtypes.

Abstract

Specific predictors (notably bpCR and MRI-rCR(LN)) are strongly associated with ypN0 in cN1 BC post-NAT, with Luminal B HER2+ patients demonstrating superior response rates. These findings support selective SLNB omission in cN1 patients achieving these key response markers.

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