This research investigates how KMT2B influences RAI sensitivity in thyroid cancer through epigenetic modifications.
Analyzed the role of KMT2B in thyroid carcinoma cell lines
Examined H3K4 trimethylation and its effects on RBBP6 expression
Studied the interaction affecting STAT1 and DPP4.
KMT2B significantly increased H3K4 trimethylation at the RBBP6 promoter.
Upregulation of RBBP6 promoted STAT1 degradation, leading to reduced DPP4 levels.
Enhanced RAI sensitivity was observed in thyroid carcinoma cells influenced by KMT2B.
Abstract
KMT2B enhanced RAI sensitivity in THCA via H3K4me3-mediated RBBP6 upregulation, driving STAT1 ubiquitination and degradation to suppress DPP4 transcription.