What question did this study set out to answer?

This research aims to analyze the long-term outcomes of isolated locoregional recurrence in breast cancer patients and identify prognostic factors.

April 23, 2026Open Access

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Long-term outcome of isolated locoregional (ILRR) breast cancer (BC) recurrence: a large retrospective Mono-institutional study

GVGrazia VernaciIstituto Oncologico Veneto GGGaia Griguolo FGFabio GirardiIstituto Oncologico Veneto

Key Points

This research aims to analyze the long-term outcomes of isolated locoregional recurrence in breast cancer patients and identify prognostic factors.
Conducted a large retrospective analysis at a single institution
Evaluated patient outcomes following curative treatment for primary breast cancer
Assessed factors like HR loss in biological recharacterization
Patients with ILRR face a higher risk of disease recurrence
Biological markers, such as HR loss, may serve as prognostic factors
Personalization of treatment and follow-up strategies is suggested based on findings

Abstract

Patients diagnosed with ILRR after curative treatment for primary BC are at higher risk of subsequent DR, highlighting the need for prompt diagnosis and treatment of ILRR. Moreover, biological recharacterization of ILRR provides potential key prognostic and predictive factors, such as HR loss, allowing personalization of treatment and follow-up after ILRR.

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Cite This Study

Vernaci et al. (Fri,) studied this question.

synapsesocial.com/papers/69e9bb9e85696592c86ed375 https://doi.org/https://doi.org/10.1093/oncolo/oyag141

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