A 46-year-old woman presenting with acute coronary syndrome-like symptoms and deep T-wave inversions was diagnosed with apical hypertrophic cardiomyopathy and managed conservatively with beta-blockers.
Case Report (n=1)
No
Apical hypertrophic cardiomyopathy should be considered in the differential diagnosis of patients presenting with ACS-like symptoms and deep T-wave inversions but normal coronary arteries.
Apical hypertrophic cardiomyopathy (ApHCM), or Yamaguchi syndrome, is a morphological variant of hypertrophic cardiomyopathy that frequently mimics acute coronary syndrome (ACS) due to ischemic-type chest pain and characteristic electrocardiographic changes. A 46-year-old woman presented with angina and deep T-wave inversion in precordial leads. Coronary angiography showed normal epicardial arteries. Transthoracic echocardiography revealed localized left ventricular apical hypertrophy with preserved systolic function and the typical "ace-of-spades" cavity configuration, confirming ApHCM. She was managed conservatively with beta-blockers and guideline-directed therapy, with symptomatic improvement. Early recognition prevents unnecessary invasive procedures and facilitates appropriate long-term management.
Lokesh Shirbhate (Tue,) conducted a case report in Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) (n=1). Beta-blockers and guideline-directed therapy was evaluated. A 46-year-old woman presenting with acute coronary syndrome-like symptoms and deep T-wave inversions was diagnosed with apical hypertrophic cardiomyopathy and managed conservatively with beta-blockers.