BACKGROUND: Nuclear factor kappa B (NF-κB) is a key regulator of inflammatory responses involved in chronic inflammatory diseases. Bioactive compounds from ginger ( METHODS: Eligible studies included peer-reviewed English preclinical in vitro and in vivo studies assessing ginger-derived nanoparticles targeting NF-κB mediated inflammation; reviews, clinical studies, and non-nanoparticle ginger formulations were excluded. Databases searched were PubMed, ScienceDirect, SpringerLink, the Cochrane Library, Scopus, Web of Science, and Embase (January 2010 to August 2025). Risk of bias was assessed using SYRCLE, SciRAP, and MISEV 2018 tools, and findings were narratively synthesized due to methodological heterogeneity. RESULTS: Seven preclinical studies were included. Ginger-derived nanoparticles consistently suppressed canonical NF-κB signaling by inhibiting IκBα phosphorylation and p65 nuclear translocation, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), oxidative stress, and tissue inflammation. Evidence was limited by small study numbers, heterogeneous nanoparticle formulations, and reliance on preclinical data, preventing meta-analysis. CONCLUSION: Ginger-derived nanoparticles represent a promising experimental strategy for modulating inflammatory signaling pathways in preclinical models. PROTOCOL REGISTRATION: PROSPERO (CRD420261337393). Inflammation is the body’s natural response to injury or infection, but long-lasting inflammation can contribute to many chronic diseases. A key driver of inflammation is a signaling pathway called nuclear factor kappa B (NF-κB). Compounds found in ginger are known to reduce inflammation, but their effects in the body are limited because they are unstable and poorly absorbed. Recent studies have shown that packaging ginger compounds into very small particles, known as ginger-derived nanoparticles, may improve their delivery and effectiveness. This review summarizes evidence from laboratory and animal studies showing that these nanoparticles can block NF-κB activity, reduce inflammatory chemicals, and lessen tissue damage in several disease models. Overall, ginger-derived nanoparticles may represent a promising experimental approach for modulating inflammatory responses in preclinical models. More research is needed to confirm their long-term safety and effectiveness in humans.
Wirattami et al. (Wed,) studied this question.