Hypertension Drives Protein Lactylation and Vascular Dysfunction in Skeletal Muscle

Key Points

• To understand how hypertension affects protein lactylation and vascular function in skeletal muscle.
• Investigated the impact of hypertension on skeletal muscle metabolism
• Analyzed protein lactylation levels in hypertensive conditions
• Explored lactate-mediated signaling pathways
• Hypertension leads to increased protein lactylation in skeletal muscle
• Vascular dysfunction is linked to impaired muscle-vascular communication
• Persistent lactate accumulation contributes to metabolic disturbances