Abstract Sinonasal hamartomas are rare, benign developmental lesions of the nasal cavity that may mimic inflammatory polyps or neoplastic processes, particularly when presenting as unilateral nasal masses. Accurate diagnosis is essential to prevent unnecessary aggressive management. We report the case of a 43-year-old male with a history of chronic rhinosinusitis who presented with progressive right-sided nasal obstruction and was found to have a unilateral nasal cavity mass. The patient underwent endoscopic excision of the lesion with clear margins. Gross pathologic examination revealed irregular tan-pink mucosal and cartilaginous tissue fragments measuring up to ~2.5 cm. Histopathologic analysis demonstrated disorganized sinonasal elements without cytologic atypia, invasive growth, or malignant features, consistent with a sinonasal hamartoma. The postoperative course was uncomplicated, and no further intervention was required. This case highlights the importance of considering hamartomas in the differential diagnosis of unilateral nasal masses and demonstrates that complete endoscopic excision is both diagnostic and curative.
Witte et al. (Wed,) studied this question.