What question did this study set out to answer?

Investigate the molecular interactions of BMS-984923 with Alzheimer's amyloid-beta structures to understand its inhibitory effects.

April 24, 2026

Computational investigation of BMS-984923 against Alzheimer’s Amyloid-beta (Ab) structures : Insights into their molecular interactions and inhibition of aggregation

Key Points

Investigate the molecular interactions of BMS-984923 with Alzheimer's amyloid-beta structures to understand its inhibitory effects.
Conducted computational studies to simulate molecular interactions with amyloid-beta.
Analyzed the potential for BMS-984923 to inhibit aggregation of Aβ peptides.
BMS-984923 demonstrated effective binding to amyloid-beta structures.
The compound significantly inhibited the formation of oligomers and protofibrils.

Abstract

Normal brain function involves soluble Aβ peptides that support synaptic activity. However, Aβ peptides are prone to aggregation under abnormal or pathogenic conditions, forming clumps known as oligomers and protofibrils,...

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Cite This Study

Patir et al. (Thu,) studied this question.

synapsesocial.com/papers/69eb0bfa553a5433e34b57a4 https://doi.org/https://doi.org/10.1039/d5cp04916d

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