Coronary artery disease, peripheral artery disease, and ischemic stroke share most genetic risk loci but exhibit many disease-specific loci and markedly different risk factor effect sizes.
Atherosclerotic cardiovascular diseases (CAD, PAD, IS) share etiologic genetic factors but also exhibit substantial disease-specific genetic differences.
Absolute Event Rate: 0% vs 0%
Aim of the studyTo study shared and distinct genetic features of coronary artery disease (CAD), peripheral artery disease (PAD), and ischemic stroke (IS).Main findings (A) Heritability was highest for CAD.(B) While the majority of risk loci overlapped, CAD, PAD and IS displayed many disease-specific loci.(C) Likewise, the genetic underpinnings of risk factors displayed markedly different effect sizes across the three diseases. ConclusionAtherosclerotic cardiovascular diseases share etiologic factors yet exhibit substantial genetic differences.
Li et al. (Wed,) reported a other. Coronary artery disease, peripheral artery disease, and ischemic stroke share most genetic risk loci but exhibit many disease-specific loci and markedly different risk factor effect sizes.
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