Establishment of a BALB/c Mouse Model for Photoaged Skin: Insights into UV‐Induced Dermatological Changes

Key Points

• The aim is to create a mouse model that closely simulates human skin photoaging due to UV exposure.
• Utilized a BALB/c mouse model to simulate photoaging under chronic UV exposure.
• Employed a two-MED (minimal erythema dose) protocol corresponding to total doses of 51.8 J/cm² UVA and 5.53 J/cm² UVB.
• The mouse model exhibited dermatological changes similar to human photoaging features.
• Skin responses in the model can facilitate comprehensive investigations into photoaging mechanisms and potential interventions.