Synthesis of Organic HCl Salts via Mechanochemical Salification and their Characterization with 35/37 Cl Solid-State NMR Spectroscopy

Key Points

• The aim is to synthesize hydrochloride salts through mechanochemical salification and characterize their properties.
• Utilized mechanochemical salification to produce hydrochloride salts.
• Employed solid-state NMR spectroscopy for detailed characterization.
• Assessed the physicochemical properties of the synthesized salts.
• Demonstrated improved solubility and stability of hydrochloride salts compared to other forms.
• Characterized structural features using ^35/37 Cl solid-state NMR spectroscopy.
• Highlighted the effectiveness of mechanochemical processes in synthesizing pharmaceutical salts.