What question did this study set out to answer?

This study aims to explore the relationship between vitamin D receptor polymorphisms and diabetes risk reduction through supplementation in adults with prediabetes.

April 25, 2026Open Access

Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes

Key Points

This study aims to explore the relationship between vitamin D receptor polymorphisms and diabetes risk reduction through supplementation in adults with prediabetes.
Genetic association study focused on adults with prediabetes
Participants received daily supplementation of 4000 IU/d of vitamin D3
Genotyping was performed to identify ApaI polymorphisms (AC and CC alleles)
Diabetes risk reduction was observed only in participants with AC and CC alleles of the ApaI polymorphism
Individuals carrying these alleles benefited most from high-dose vitamin D3 treatment

Abstract

This genetic association study of adults with prediabetes suggests that diabetes risk reduction after supplementation with 4000 IU/d of vitamin D3 was restricted to participants carrying the AC and CC alleles of the ApaI polymorphism. These findings support the potential role of ApaI genotyping in identifying individuals most likely to experience benefits from high-dose vitamin D3 treatment to reduce diabetes risk.

Read Full Paperexternally

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper