Local cytokine release syndrome with cervical angioedema following CAR-T cell therapy

Key Points

• This report aims to describe the occurrence of local cytokine release syndrome and its effects following CAR-T cell therapy.
• Clinical observation of symptoms following CAR-T cell treatment
• Assessment of cytokine levels during treatment
• Identification of angioedema as a side effect
• Patient developed cervical angioedema within days of receiving CAR-T cell therapy
• Significant elevation of pro-inflammatory cytokines was noted
• Symptoms improved following appropriate medical intervention