A 74-year-old male with diffuse hypertrophic obstructive cardiomyopathy and a MYBPC3 missense variant developed progressive heart failure and recurrent ventricular arrhythmias requiring 7 ICD shocks despite optimal medical therapy.
Case Report (n=1)
No
This case highlights the rare and high-risk coexistence of diffuse hypertrophic obstructive cardiomyopathy, left ventricular apical aneurysm, and excessive trabeculation, underscoring the need for close monitoring and ICD therapy.
This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 gene (c.3343G A: p.Val1115Ile). Despite optimal medical therapy and implantable cardioverter-defibrillator (ICD) implantation, the patient developed progressive cardiac dysfunction and recurrent ICD shocks. We discuss the clinical course, genetic findings, and imaging features of this case.
Li et al. (Wed,) conducted a case report in Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation (n=1). Optimal medical therapy and implantable cardioverter-defibrillator (ICD) implantation was evaluated. A 74-year-old male with diffuse hypertrophic obstructive cardiomyopathy and a MYBPC3 missense variant developed progressive heart failure and recurrent ventricular arrhythmias requiring 7 ICD shocks despite optimal medical therapy.