The Landscape of Pediatric Differentiated Thyroid Carcinoma and Predictors of Invasive Disease: A CATC Study

Key Points

• This study examines the predictors of invasive differentiated thyroid carcinoma (DTC) in pediatric patients.
• Analysis of pediatric patients diagnosed with differentiated thyroid carcinoma (DTC)
• Identification of associations between age, sex, tumor characteristics, and extrathyroidal extension (ETE)
• Evaluation of long-term disease outcomes against recent treatment trends
• Invasive DTC is significantly associated with age under 10 years and male sex.
• Tumors characterized by oncogenic fusions are linked to higher rates of invasive disease.
• Despite less aggressive treatment protocols, the outcomes of disease have remained stable.