Ent in its 2, 3-DHBA form confers mucosal protection, despite its inhibitory effects on mitochondrial respiration. These findings suggest that modulating mitochondrial activity, thus reducing cellular metabolism, may be beneficial during colitis and position 2, 3-DHBA as a promising microbiota-derived metabolite for therapeutic intervention in inflammatory bowel disease.
Kushwaha et al. (Thu,) studied this question.