What question did this study set out to answer?

The study aims to determine the lowest acceptable colonic transit time for optimal polyp detection in colon capsule endoscopy.

April 27, 2026Clinical Colorectal Cancer0 citationsOpen Access

Detection of Polyps in Colon Capsule Endoscopy and Impact of Colonic Transit Time

OSOla Selnes LHLea Østergaard Hansen BSBenedicte Schelde-Olesen

Key Points

The study aims to determine the lowest acceptable colonic transit time for optimal polyp detection in colon capsule endoscopy.
Analyzed data from Danish cancer screening participants in the CareForColon2015 trial
Used a multivariate logistic regression model to assess the impact of colonic transit time on polyp detection rate
Included 1,266 eligible participants from an initial 2,031 who underwent colon capsule endoscopy
CTT ≤20 min was significantly associated with lower polyp detection rates for all polyp sizes (OR 0.36, 95% CI 0.22; 0.59, p < 0.001)
For polyps >5 mm, a CTT ≤20 min showed reduced detection rates (OR 0.54, 95% CI 0.34; 0.85, p = 0.007)
No significant differences in polyp detection rates for polyps >9 mm across colonic transit time categories

Abstract

AbstractBackground and Aim Colon capsule endoscopy (CCE) is a non-invasive technique for colon evaluation. Although previous research has demonstrated high accuracy of CCE in detecting polyps, the impact of colonic transit time (CTT) on polyp detection remains unclear. We aimed to identify the lowest acceptable CTT for an optimal polyp detection rate (PDR). Methods This study analyzed data from Danish colorectal cancer screening participants with complete CCE examinations, as part of the CareForColon2015 trial. A multivariate logistic regression model was employed to investigate the relationship between CTT and PDR, while adjusting for pertinent factors and covariates. Results Among the 2,031 participants who underwent CCE, 1,266 (62.3 %) were eligible for analysis. The multivariate analysis showed that a CTT of ≤20 min was significantly associated with lower PDR for polyps of any size (OR 0.36, 95-CI% 0.22; 0.59, p 5 mm (OR 0.54, 95-CI% 0.34; 0.85, p = 0.007) compared to a CTT of >60 min. A non-significant trend was observed for CTTs between 21-40 min and PDR for polyps >5 mm (OR 0.68, 95-CI% 0.46; 1.01, p = 0.053). No significant differences in PDR for polyps >9 mm was found across the CTT categories. A sensitivity analysis with size-adjusted polyps revealed no significant differences in PDR for polyps >5 mm across CTT categories. Conclusions CTTs of ≤20 min are correlated with lower PDR for polyps of any size and those exceeding >5 mm, but not for polyps >9 mm. After size-adjustments of all polyps, detection rates of clinically significant polyps were deemed independent of CTT. Micro-abstract This study examined the correlation between colonic transit time and polyp detection rates in 1,266 Danish colorectal cancer screening participants undergoing colon capsule endoscopy. A CTT ≤20 minutes was associated with to reduced detection of polyps of any size and >5 mm, but not >9 mm. After size adjustment, polyp detection for polyps >5 mm was independent of CTT.

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