The CTEPH ECG SCORE distinguished chronic thromboembolic pulmonary hypertension from acute pulmonary embolism with high accuracy (AUC 0.95).
Observational (n=184)
No
Does the CTEPH ECG SCORE accurately differentiate chronic thromboembolic pulmonary hypertension from intermediate-high-risk acute pulmonary embolism?
A simple, 4-variable ECG scoring system can accurately differentiate chronic thromboembolic pulmonary hypertension from acute pulmonary embolism, potentially aiding in rapid triage and avoiding ineffective reperfusion therapies.
Effect estimate: AUC 0.95 (95% CI 0.89-0.98)
p-value: p=<0.0001
Acute pulmonary embolism (APE) and chronic thromboembolic pulmonary hypertension (CTEPH) both causedyspnoea and right ventricular (RV) overload, but require diff erent management. Electrocardiography (ECG) is widelyavailable, yet its role in distinguishing APE from CTEPH remains underexplored. We aimed to identify ECG parametersdiff erentiating APE from CTEPH and develop a predictive model.We included 184 patients: those hospitalized with intermediate-high-risk APE and patients with confi rmed CTEPH.ECG parameters were analyzed using logistic regression, and a predictive equation and simplifi ed scoring model(CTEPH ECG SCORE) were developed and validated.CTEPH patients showed higher rates of right axis deviation (RAD), qR pattern in V1, increased precordial ECGvoltage, and prolonged P-wave duration, whereas APE patients had higher heart rates, more frequent right bundlebranch blocks, and greater T-wave inversions (TWI). The CTEPH ECG SCORE distinguished CTEPH from APE with highaccuracy (AUC = 0.95) and was calculated as follows: CTEPH ECG SCORE = 0.5 + (4 × RAD) + (2 × Sokolow-Lyonindex) – (3.5 × HR 100) – (0.5 × TWI range).ECG can serve as a valuable tool for distinguishing CTEPH from APE.
Waligóra et al. (Sat,) conducted a observational in Acute pulmonary embolism and chronic thromboembolic pulmonary hypertension (n=184). CTEPH ECG SCORE was evaluated on Discrimination between CTEPH and APE (AUC 0.95, 95% CI 0.89-0.98, p=<0.0001). The CTEPH ECG SCORE distinguished chronic thromboembolic pulmonary hypertension from acute pulmonary embolism with high accuracy (AUC 0.95).