Preoperative and Pathological Discrepancies in Colorectal Cancer: A Single-Institution Retrospective Analysis Based on Mismatch Repair/BRAF V600E Status

Key Points

• The study aims to assess how well preoperative clinical staging matches postoperative pathological staging in colorectal cancer.
• Retrospective analysis conducted at a single institution.
• Included patients with stage II-III colorectal cancer with known BRAF V600E and mismatch repair status.
• Evaluated concordance between preoperative and postoperative staging.
• Found significant discrepancies in staging based on BRAF V600E status and mismatch repair status.
• Preoperative staging was often less accurate compared to postoperative findings, suggesting a need for improved diagnostic strategies.