Delayed-type hypersensitivity to low-molecular-weight heparin and cross-reactivity to fondaparinux and danaparoid in a twin pregnancy

Key Points

• This report examines an unusual hypersensitivity reaction to low-molecular-weight heparin and its alternatives in a specific pregnancy case.
• Presented a case of generalized urticaria in a twin pregnancy.
• Discussed management challenges for pregnant women intolerant of parenteral anticoagulants.
• Generalized urticaria observed in response to enoxaparin, fondaparinux, and danaparoid.
• Complicated by deep vein thrombosis in the pregnancy context.