Solvent-Free Modafinil Acid Cocrystallization through Green Melt-based Approach

Key Points

• This research aims to develop a sustainable method for cocrystal preparation using machine learning and melt-based techniques.
• Utilized predictive machine learning for screening cocrystal formations.
• Implemented a solvent-free, melt-based approach for synthesis.
• Engaged in rational crystal engineering strategies to optimize cocrystal formation.
• Achieved efficient cocrystal formation without solvents, significantly improving production speed.
• Demonstrated the effectiveness of machine learning in predicting successful cocrystallization scenarios.