Background: Mesenchymal stem cells (MSCs) are widely studied for bone healing due to their osteogenic potential and paracrine immunomodulatory and angiogenic effects. However, a quantitative overview of long-term research trends remains limited. Methods: A bibliometric analysis was conducted using the Web of Science Core Collection. Records published between 1994 and 2025 (with partial indexing for 2026) were retrieved using a Topic search combining MSC-related and bone-healing terms. Only English-language articles and reviews were included. Bibliographic data were analyzed in RStudio using Bibliometrix (Biblioshiny) to evaluate annual scientific production, citation indicators, leading journals, authors, affiliations, corresponding-author countries, collaboration, and frequent words. Results: The final dataset included 490 documents from 238 sources, with an annual growth rate of 2.19% and an average of 43.11 citations per document. Publication output increased markedly after 2010 and peaked in 2019 (44 articles). Collaboration was extensive (7.56 co-authors per document) with 24.08% international co-authorship. Core journals included Stem Cell Research and Therapy, Biomaterials, and Tissue Engineering Part A. China and the USA led corresponding-author output, while several countries showed higher proportions of international collaboration. The most frequent terms highlighted dominant themes in MSC biology, osteogenesis, cell therapy, and tissue engineering. Conclusion: MSC-assisted bone healing research shows sustained growth, strong impact, and multidisciplinary collaboration, with a thematic focus on osteogenesis and biomaterials-enabled regenerative strategies.
Nader Tanideh (Wed,) studied this question.