What question did this study set out to answer?

This study aimed to evaluate the effectiveness of a tailored therapeutic assessment (FRAX-TA) with a single-session CBT component for women at genetic risk for FXAND.

April 28, 2026Open Access

Optimizing single-session CBT delivery in an 8-session longitudinal therapeutic assessment (FRAX-TA) for women with FMR1 Premutation

Key Points

This study aimed to evaluate the effectiveness of a tailored therapeutic assessment (FRAX-TA) with a single-session CBT component for women at genetic risk for FXAND.
Eighty-one Italian women with FMR1 premutation participated in an 8-week TA protocol.
Participants were randomized into four groups based on when they received a psychoeducational assessment during the treatment period.
Bayesian ANOVAs analyzed psychological changes over time and effects of assessment timing.
Significant reductions in anxiety, depression, and distress scores were observed (exact metrics not provided).
Immediate and delayed effects were noted, especially regarding depression and anxiety after the psychoeducational assessment.
Mid-phase assessments resulted in increased perceived positive change, with high participant satisfaction reported.

Abstract

Background Therapeutic Assessment (TA) is a client-centered approach that uses psychological evaluation to promote therapeutic change. While TA has shown benefits across populations, its application to genetically at-risk groups remains limited. Women with the FMR1 premutation (PM) are vulnerable to mood, anxiety, and cognitive symptoms, collectively referred to as Fragile X-associated Neuropsychiatric Disorders (FXAND). However, tailored psychological assessments for this population are still lacking. This study introduces FRAX-TA, a TA-based protocol for women with the PM, integrating a Single-Session Cognitive Behavioral Therapy (SS-CBT) component: the Psychoeducational Assessment (PA). The aim was to offer psychological support, while collecting quantitative data. We also explored whether varying the timing of the PA influences outcomes. Methods Eighty-one Italian women with genetically confirmed PM (M age = 50.5 ± 9.41) completed an 8-week TA protocol based on the Cognitive Behavioral Assessment for Outcome Evaluation (CBA-VE). Participants were randomized into four groups receiving the PA during the 4th, 6th, 8th, or 10th week from baseline. Mixed-design Bayesian ANOVAs assessed changes across timepoints (baseline, post-PA, follow-up) and the effect of the PA timing on the five CBA-OE psychological domains (anxiety, wellbeing, perception of positive change, depression, and psychological distress). An anonymous feedback questionnaire evaluated participant experiences. Results Participants showed significant reductions in the CBA-VE anxiety, depression, and distress scores. The PA had both immediate and delayed effects, particularly for depression and anxiety. Mid-phase delivery led to more stable improvements in CBA-VE perceived positive change. Qualitative feedback indicated high satisfaction and emotional support. Conclusion FRAX-TA appears effective for women with the PM, providing therapeutic benefit even without ongoing treatment. Findings underscore the added value of SS-CBT within assessment and suggest that repeated sessions may enhance symptom recognition and prompt further care. Future studies should include control groups, larger samples, and examine personalized timing to optimize outcomes.

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Cite This Study

Montanaro et al. (Fri,) studied this question.

synapsesocial.com/papers/69f04d9f727298f751e71eac https://doi.org/https://doi.org/10.3389/fnmol.2026.1718675

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