Comparative Analysis of Tumor‐Immune Microenvironment Diversity Among Biopsy, Resection, and Metastatic Colorectal Cancer Specimens

Key Points

• The study aims to analyze the diversity of the tumor-immune microenvironment among different colorectal cancer specimens.
• Examined CD4+T/CD8+T cell infiltration and PD-L1 expression in biopsy, resection, and metastatic specimens.
• Compared tumor infiltration patterns and microsatellite instability between metastatic and nonmetastatic colorectal cancer.
• CD4+T/CD8+T cell infiltration and PD-L1 expression differ significantly between resected and metastatic specimens.
• Metastatic CRC shows notable differences in tumor infiltration and microsatellite instability compared to nonmetastatic CRC.