What question did this study set out to answer?

To develop a dual-signal aptasensor for the simultaneous detection of miR-21 and miR-155 as breast cancer biomarkers.

April 29, 2026Langmuir1 citations

Simultaneous Electrochemical Detection of miR-21 and miR-155 Breast Cancer Biomarkers Using a Dual-Signal Aptasensor Based on Cu/Cd Redox Probes

MAMohammad Mahdi Alemnezhad AGAli Ghaffarinejad HSHamid Shahbazmohammadi

Key Points

To develop a dual-signal aptasensor for the simultaneous detection of miR-21 and miR-155 as breast cancer biomarkers.
Utilized dual-signal aptasensor with Cu/Cd redox probes for detection.
Tested in human plasma samples for validation.
Evaluated selectivity, repeatability, and reproducibility over three weeks.
Achieved limits of detection of 62.0 aM for miR-21 and 650.0 aM for miR-155.
Recovery values in plasma samples ranged from 92% to 119% indicating reliability.
Demonstrated excellent selectivity and stable performance.

Abstract

M, with ultralow limits of detection of 62.0 aM for microRNA-21 and 650.0 aM for microRNA-155. The platform demonstrated excellent selectivity, good repeatability and reproducibility, and stable performance for up to 3 weeks. Successful validation in human plasma samples with recovery values between 92% and 119% confirmed the reliability of the proposed system. Overall, this dual-channel biosensor provides a robust and ultrasensitive platform for multiplexed microRNA detection and shows strong potential for early stage breast cancer diagnostics.

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Cite This Study

Alemnezhad et al. (Mon,) studied this question.

synapsesocial.com/papers/69f154e0879cb923c4945170 https://doi.org/https://doi.org/10.1021/acs.langmuir.6c00713

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