Design, synthesis, and anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids: in vitro and computational insights into EGFR inhibition

Key Points

• The research aims to design and evaluate novel pyrrole-pyrazoline hybrids for anticancer activity.
• Synthesis of new pyrrole-pyrazoline/chalcone hybrids
• Biological evaluation for anticancer effects
• Assessment of EGFR inhibition
• In vitro testing on MCF-7 cancer cells
• Compound 6b identified as a potent EGFR inhibitor
• Significant antiproliferative activity observed against MCF-7 cells
• Demonstrated potential for anticancer applications