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April 29, 2026Microbiology Spectrum0 citationsOpen Access

Genomic and functional approaches point to potential determinants of neonatal K. pneumoniae sepsis

MRManisha RoutRegional Centre for Biotechnology KRK Aksa RaniSRM University DMDr Jharana MahantaSiddhartha Medical College

Key Points

To explore the genomic and functional determinants of neonatal K. pneumoniae sepsis and their impact on clinical outcomes.
Analyzed positive strains for genomic features and epithelial fitness
Correlated findings with clinical outcomes in a neonatal cohort
Positive strains demonstrated enhanced epithelial fitness
Associated with negative clinical outcomes in the cohort
Suggested incorporation of genomic markers into neonatal sepsis risk stratification

Abstract

-positive strains exhibit enhanced epithelial fitness and are associated with adverse clinical outcomes in this cohort. These findings highlight the importance of incorporating pathogen genomic and functional markers into neonatal sepsis research, surveillance, and future risk-stratification strategies.

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Cite This Study

Rout et al. (Mon,) studied this question.

synapsesocial.com/papers/69f19f9cedf4b468248066ec https://doi.org/https://doi.org/10.1128/spectrum.04118-25

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