Synthesis, anticancer activity, and molecular docking studies of some maleimide derivatives

Key Points

• The study aims to evaluate the synthesis and anticancer properties of maleimide derivatives against specific cancer cell lines.
• Synthesis of 4-(2,5-dioxo-2,5-dihydro-1 H -pyrrol-1-yl)-N′-[(substituted phenyl)methylidene]benzohydrazides (BF 1–12)
• In vitro screening against K562 and KG-1 cancer cell lines
• BF 1–12 showed varying levels of anticancer activity against K562 and KG-1 cell lines.
• Specific maleimide derivatives demonstrated significant inhibition of cancer cell growth.
• Further molecular docking studies indicated strong binding affinities for the synthesized compounds.