First tetrametallic 19-nuclear CeIII–ScIII–WVI–SbIII cluster-incorporated polyoxometalate for electrochemical biosensing of CYFRA21-1

Key Points

• The research aims to develop a novel tetrametallic cluster-integrated polyoxometalate for the detection of the lung cancer biomarker CYFRA21-1.
• Developed a novel tetrametallic cluster incorporating CeIII, ScIII, WVI, and SbIII within a polyoxometalate framework.
• Utilized electrochemical techniques for biosensing assessment of CYFRA21-1 levels in serum samples.
• Showed a significant increase in sensitivity for the detection of CYFRA21-1 compared to traditional methods.
• Achieved a detection limit of 0.01 ng/mL, enhancing early diagnosis potential.