The Predictive Value of the Substantia Nigra and Locus Coeruleus Volumes Using 3D Neuromelanin-sensitive MRI to Predict the Outcomes after Deep Brain Stimulation in Advanced Parkinson's Disease: An Exploratory Study

Key Points

• To investigate how the volumes of the substantia nigra and locus coeruleus influence symptoms post-deep brain stimulation in advanced Parkinson's disease.
• Exploratory study utilizing 3D neuromelanin-sensitive MRI for volume measurement.
• Focused on motor and non-motor symptoms following deep brain stimulation.
• Sample included patients diagnosed with advanced Parkinson's disease.
• Significant correlation between substantia nigra and locus coeruleus volumes and symptom outcomes post-DBS.
• Findings indicate the potential of these brain volumes as predictive biomarkers for therapy response.
• Results support the use of advanced imaging techniques in neurodegenerative disease assessment.