Background To evaluate the clinical efficacy of ciprofol versus propofol combined with alfentanil for anesthesia in patients undergoing hysteroscopic transcervical resection of submucosal myomas. Methods A total of 208 patients scheduled for hysteroscopic transcervical resection of submucosal myomas were randomly allocated into ciprofol (group C) and propofol (group P) groups after exclusion. All patients received intravenous alfentanil 10 μg/kg before induction. The group C received intravenous ciprofol 0.4 mg/kg, while the group P received intravenous propofol 2.0 mg/kg. After anesthesia induction, a laryngeal mask airway was inserted. Anesthesia was maintained with a continuous infusion of ciprofol 0.8 mg/(kg·h) or propofol 5 mg/(kg·h) using a micro-infusion pump until the end of surgery. Mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) were recorded at the following time points: Pre-anesthesia (T0), after anesthesia induction (T1), during cervical dilation (T2), during electrosurgical resection (T3), and at the end of surgery (T4). Total dosage of study drug, recovery time, orientation recovery time, visual analogue scale (VAS) scores for uterine contraction pain after awakening, and adverse events were recorded. Results Intraoperative decreases in MAP and HR were significantly greater in the group P than in the group C ( p 0.05). The total anesthetic dosage was significantly higher in the group P ( p 0.05). Recovery time and orientation recovery time were longer in the group C compared with the group P ( p 0.05). VAS scores at 5 and 15 min after awakening were significantly lower in the ciprofol group ( p 0.05). The incidence of injection pain was much higher in Group P than that in Group C ( p 0.001). The rate of respiratory inhibition was significantly lower in Group C than that in Group P ( p 0.05). Conclusion Ciprofol exhibits comparable efficacy to that of propofol. It has good analgesic activity, more stable hemodynamics, and minimal respiratory disturbance, less injection pain rate in hysteroscopic transcervical resection of submucosal myoma.
Li et al. (Tue,) studied this question.