Vibrio cholerae O1 classical and El Tor toxin-coregulated pilus subunit A (TcpA) epitopes that induce biotype-specific and cross-protective antibodies against bacterial adherence.

Key Points

• The aim is to identify which TcpA epitopes induce biotype-specific and cross-protective antibodies against Vibrio cholerae adherence.
• Analyzed TcpA epitopes from Vibrio cholerae O1 classical and El Tor biotypes.
• Evaluated the immune response against bacterial adherence in vitro.
• Compared antibody production between different TcpA variants.
• Specific antibody responses were detected against TcpA epitopes from both biotypes.
• Cross-reactivity observed with similar epitope patterns for both classical and El Tor strains.
• Findings indicate potential for developing a vaccine that provides broad protection against cholera.