AIMS: Advanced rehabilitation technologies are progressively integrated into stroke rehabilitation. However, their capacity to elicit neurological benefits via neuroplasticity biomarkers, particularly brain-derived neurotrophic factor (BDNF), and their association with functional recovery remain poorly understood. This review aimed to systematically evaluate the effectiveness of technology-assisted rehabilitation on blood-based biomarkers in stroke patients, discuss their potential link to functional recovery, and quantitatively analyze BDNF through meta-analysis. METHODS: We conducted a systematic review and a meta-analysis of studies published from January 2010 to July 2025. A comprehensive search was performed using PubMed, Scopus, and Cochrane Library. Screening was conducted using Rayyan software, and analysis was performed using SPSS Statistics. RESULTS: = 0.01). CONCLUSIONS: Technology-assisted rehabilitation may influence neural repair biomarkers, suggesting a potential role in stroke recovery. However, inconsistencies across studies, particularly short intervention durations and heterogeneous study designs, indicate the need for high-quality and longitudinal investigations.
Noor et al. (Thu,) studied this question.